Article
Differential expression of CD10 in prostate cancer and its clinical implication.
BMC urology - 2 Mar 2007
Dall'Era Marc A, True Lawrence D, Siegel Andrew F, Porter Michael P, Sherertz Tracy M, Liu Alvin Y
Abstract excerpt
BACKGROUND: CD10 is a transmembrane metallo-endopeptidase that cleaves and inactivates a variety of peptide growth factors. Loss of CD10 expression is a common, early event in human prostate cancer; however, CD10 positive cancer cells frequently appear in lymph node metastasis. We hypothesize that prostate tumors expressing high levels of CD10 have a more aggressive biology with an early propensity towards lymph...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.