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Article

POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in head and neck cancer.

Oncotarget - 30 Sept 2014

Sharpe Daniel J, Orr Katy S, Moran Michael, White Sharon J, McQuaid Stephen, Lappin Terence R, Thompson Alexander, James Jacqueline A

Abstract excerpt

HOX genes are master regulators of organ morphogenesis and cell differentiation during embryonic development, and continue to be expressed throughout post-natal life. To test the hypothesis that HOX genes are dysregulated in head and neck squamous cell carcinoma (HNSCC) we defined their expression profile, and investigated the function, transcriptional regulation and clinical relevance of a subset of highly...

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Share to Carcinoma, Squamous Cell
Share to Head and Neck Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasm Invasiveness

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Source

Open in PubMed Open full text

Identifiers

PMID: 25301728
DOI: 10.18632/oncotarget.2492
PMCID: PMC4226723

Genes

HOXD10
HOXD11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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