Potential Influence of TNFSF15 Genetic Variants and Expression Levels on Disease Progression in Patients With Hepatocellular Carcinoma.

doi:10.1002/mc.70026

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Article

Potential Influence of TNFSF15 Genetic Variants and Expression Levels on Disease Progression in Patients With Hepatocellular Carcinoma.

Molecular carcinogenesis - 1 Oct 2025

Hsueh Kuan-Chun, Hsieh Yi-Hsien, Su Shih-Chi, Wu Edie-Rosmin, Chang Lun-Ching, Yang Shun-Fa, Lee Hsiang-Lin

Abstract excerpt

Hepatocellular carcinoma (HCC), whose complex etiology involves a genetic component, is a global public health burden. Tumor necrosis factor superfamily member 15 (TNFSF15) is a T lymphocyte-costimulatory cytokine known to modulate angiogenesis and inflammation, implicating its potential role in cancer development. In this study, we attempted to explore the influence of TNFSF15 gene variations on the risk for...

Read the complete abstract on PubMed

Topics

Humans
Carcinoma, Hepatocellular
Liver Neoplasms
Tumor Necrosis Factor Ligand Superfamily Member 15
Male
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Middle Aged

Disease Progression

Genetic Predisposition to Disease

Case-Control Studies

Aged

Gene Expression Regulation, Neoplastic

Adult

Alleles

Source

Open in PubMed

Identifiers

PMID: 40762626
DOI: 10.1002/mc.70026

Genes

TNFSF15

Provenance

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