Association Between a Variant in ADAMTS5 and the Susceptibility to Hepatocellular Carcinoma in a Chinese Han Population.

doi:10.1007/s12013-014-0441-3

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Article

Association Between a Variant in ADAMTS5 and the Susceptibility to Hepatocellular Carcinoma in a Chinese Han Population.

Cell biochemistry and biophysics - 1 May 2015

Li Chongyi, Xiong Yanli, Zhong Zhaoyang, Zhang Shiheng, Peng Yu, Wang Lin'ang, Dai Nan, Li Mengxia, Ren Tao, Gan Lixia, Wang Dong

Abstract excerpt

A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is considered to be an important anti-angiogenic protein, in which the first TSR domain is crucial for its anti-angiogenic activity. Previous study showed that ADAMTS5 plays a role in suppression of hepatocellular carcinoma (HCC) progression through its anti-angiogenic activity. The rs2380585 G>A single-nucleotide polymorphism (SNP) is a...

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PMID: 25519309
DOI: 10.1007/s12013-014-0441-3

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ADAMTS5

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