Article
Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2017
Abbasi M Reza, Rifatbegovic Fikret, Brunner Clemens, Mann Georg, Ziegler Andrea, Pötschger Ulrike, Crazzolara Roman, Ussowicz Marek, Benesch Martin, Ebetsberger-Dachs Georg, Chan Godfrey C F, Jones Neil, Ladenstein Ruth, Ambros Inge M, Ambros Peter F
Abstract excerpt
Purpose: Tumor relapse is the most frequent cause of death in stage 4 neuroblastomas. Since genomic information on the relapse precursor cells could guide targeted therapy, our aim was to find the most appropriate tissue for identifying relapse-seeding clones.Experimental design: We analyzed 10 geographically and temporally separated samples of a single patient by SNP array and validated the data in 154 stage 4...
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