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epiG: statistical inference and profiling of DNA methylation from whole-genome bisulfite sequencing data.

Genome biology - 21 Feb 2017

Vincent Martin, Mundbjerg Kamilla, Skou Pedersen Jakob, Liang Gangning, Jones Peter A, Ørntoft Torben Falck, Dalsgaard Sørensen Karina, Wiuf Carsten

Abstract excerpt

The study of epigenetic heterogeneity at the level of individual cells and in whole populations is the key to understanding cellular differentiation, organismal development, and the evolution of cancer. We develop a statistical method, epiG, to infer and differentiate between different epi-allelic haplotypes, annotated with CpG methylation status and DNA polymorphisms, from whole-genome bisulfite sequencing data,...

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Identifiers

PMID: 28222791
DOI: 10.1186/s13059-017-1168-4
PMCID: PMC5320668

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Source receipt: pubmed, retrieved 7 Sept 2026.

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