Article
Patterns of pncA mutations in drug-resistant Mycobacterium tuberculosis isolated from patients in South Korea.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease - 1 Jan 2012
Kim H J, Kwak H K, Lee J, Yun Y J, Lee J S, Lee M S, Min S Y, Park S K, Kang H S, Maeng Y H, Kim S Y, Kim S Y, Kook Y H, Kim Y R, Lee K H
Abstract excerpt
BACKGROUND: Pyrazinamide (PZA), one of the most effective anti-tuberculosis drugs, becomes toxic to Mycobacterium tuberculosis when converted to pyrazinoic acid by pyrazinamidase (PZase). PZA resistance is caused mainly by the loss of enzyme activity by mutation. OBJECTIVE: To investigate the patterns of pncA mutations in PZA-resistant mycobacteria isolated from South Korean patients. METHODS: Mycobacterial...
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