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Article

Pyrazinamide resistance and pncA gene mutations in Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 May 2008

Juréen Pontus, Werngren Jim, Toro Juan-Carlos, Hoffner Sven

Abstract excerpt

Thirty-four pyrazinamide-resistant and 37 pyrazinamide-susceptible Mycobacterium tuberculosis complex strains were analyzed for pncA gene mutations. None of the sensitive strains had any mutations, apart from silent mutations, whereas all but one resistant strain showed pncA mutations. By using sequencing as a means of early resistance detection, the inconsistency of phenotypic pyrazinamide assays can be...

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Identifiers

PMID: 18316515
DOI: 10.1128/AAC.00110-08
PMCID: PMC2346646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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