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A PLCB1–PI3K–AKT Signaling Axis Activates EMT to Promote Cholangiocarcinoma Progression

27 Sept 2021

Abstract excerpt

Abstract As a member of the phospholipase family, phospholipase C beta 1 (PLCB1) is involved in phospholipid hydrolysis and is frequently upregulated in human cancer. However, little is known about the role of PLCB1 in cholangiocarcinoma (CCA). In this study, we uncover a role for PLCB1 in CCA progression and identify the underlying mechanisms. Both human CCA tissues and CCA cell lines expressed high levels of...

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Share to Cholangiocarcinoma and Gallbladder Cancer Studies
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PMID: 34580062
DOI: 10.1158/0008-5472.can-21-1538

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