Article
Suramin interacts with the positively charged region surrounding the 5-fold axis of the EV-A71 capsid and inhibits multiple enterovirus A.
Scientific reports - 20 Feb 2017
Ren Peijun, Zheng Yimei, Wang Wenqi, Hong Liping, Delpeyroux Françis, Arenzana-Seisdedos Fernando, Altmeyer Ralf
Abstract excerpt
Suramin was previously shown to bind to the EV-A71 capsid through its naphthalenetrisulfonic acid groups, thereby reducing virus-cell binding and inhibiting viral replication. Here, we identify VP1-145 as the critical amino acid that accounts for the differential sensitivity of EVA-71 viruses to suramin. A single Q or G to E substitution at VP1-145 results in an approximately 30-fold shift of IC50 or IC90 values...
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