Article
Characterization of three small molecule inhibitors of enterovirus 71 identified from screening of a library of natural products.
Antiviral research - 1 Jul 2017
Li Guiming, Gao Qianqian, Yuan Shilin, Wang Lili, Altmeyer Ralf, Lan Ke, Yin Feifei, Zou Gang
Abstract excerpt
Enterovirus 71 (EV-A71) is a major cause of hand, foot, and mouth disease (HFMD). Infection with EV-A71 is more often associated with neurological complications in children and is responsible for the majority of fatalities, but currently there is no approved antiviral therapy for treatment. Here, we identified auraptene, formononetin, and yangonin as effective inhibitors of EV-A71 infection in the low-micromolar...
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