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Rosmarinic acid exhibits broad anti-enterovirus A71 activity by inhibiting the interaction between the five-fold axis of capsid VP1 and cognate sulfated receptors.

Emerging microbes & infections - 1 Dec 2020

Hsieh Chung-Fan, Jheng Jia-Rong, Lin Guan-Hua, Chen Yu-Li, Ho Jin-Yuan, Liu Chien-Jou, Hsu Kuei-Yang, Chen Yuan-Siao, Chan Yoke Fun, Yu Hui-Ming, Hsieh Pei-Wen, Chern Jyh-Haur, Horng Jim-Tong

Abstract excerpt

Enterovirus A71 (EV-A71), a positive-stranded RNA virus of the Picornaviridae family, may cause neurological complications or fatality in children. We examined specific factors responsible for this virulence using a chemical genetics approach. Known compounds from an anti-EV-A71 herbal medicine, Salvia miltiorrhiza (Danshen), were screened for anti-EV-A71. We identified a natural product, rosmarinic acid (RA), as...

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Identifiers

PMID: 32397909
DOI: 10.1080/22221751.2020.1767512
PMCID: PMC7448925

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