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Article

Comprehensive profiling and quantitation of oncogenic mutations in non-small cell lung carcinoma using single-molecule amplification and re-sequencing technology.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Feb 2017

Shi Jian, Yuan Meng, Wang Zhan-Dong, Xu Xiao-Li, Hong Lei, Sun Shenglin

Abstract excerpt

The carcinogenesis of non-small cell lung carcinoma has been found to associate with activating and resistant mutations in the tyrosine kinase domain of specific oncogenes. Here, we assessed the type, frequency, and abundance of epithelial growth factor receptor, KRAS, BRAF, and ALK mutations in 154 non-small cell lung carcinoma specimens using single-molecule amplification and re-sequencing technology. We found...

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Identifiers

PMID: 28218040
DOI: 10.1177/1010428317691413

Genes

ALK
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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