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Article

Comprehensive profiling and quantitation of oncogenic mutations in non small-cell lung carcinoma using single molecule amplification and re-sequencing technology.

Oncotarget - 2 Aug 2016

Zhang Shirong, Xia Bing, Jiang Hong, Wang Limin, Xu Rujun, Shi Yanbin, Zhang Jianguang, Xu Mengnan, Cram David S, Ma Shenglin

Abstract excerpt

Activating and resistance mutations in the tyrosine kinase domain of several oncogenes are frequently associated with non-small cell lung carcinoma (NSCLC). In this study we assessed the frequency, type and abundance of EGFR, KRAS, BRAF, TP53 and ALK mutations in tumour specimens from 184 patients with early and late stage disease using single molecule amplification and re-sequencing technology (SMART). Based on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27409166
DOI: 10.18632/oncotarget.10464
PMCID: PMC5226597

Genes

EGFR
ALK
BRAF
KRAS
EML4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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