Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

miR-194-5p/BCLAF1 deregulation in AML tumorigenesis

20 Feb 2017

Abstract excerpt

Deregulation of epigenetic mechanisms, including microRNA, contributes to leukemogenesis and drug resistance by interfering with cancer-specific molecular pathways. Here, we show that the balance between miR-194-5p and its newly discovered target BCL2-associated transcription factor 1 (BCLAF1) regulates differentiation and survival of normal hematopoietic progenitors. In acute myeloid leukemias this balance is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Epigenetics and DNA Methylation
Share to Histone Deacetylase Inhibitors Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28216661
DOI: 10.1038/leu.2017.64

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

miR-194-5p/BCLAF1 deregulation in AML tumorigenesisPMID 28216661Read ↗

Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemiaSemantic proximity Read ↗

BCL-2 family proteins as 5-Azacytidine-sensitizing targets and determinants of response in myeloid malignanciesSemantic proximity Read ↗

miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potentialSemantic proximity Read ↗

The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis.Semantic proximity Read ↗

The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesisSemantic proximity Read ↗

Crosstalk between EZH2 and BCL6 in regulating chronic myeloid leukaemia (CML) stem cell survival : from epigenomics to novel therapeutic approachesSemantic proximity Read ↗

Role of SIRT1 in Chemoresistant LeukemiaSemantic proximity Read ↗

An alternative NURF complex sustains acute myeloid leukemia by regulating the accessibility of insulator regionsSemantic proximity Read ↗

H22954, a novel long non-coding RNA down-regulated in AML, inhibits cancer growth in a BCL-2-dependent mechanismSemantic proximity Read ↗

Expression Levels of Warburg-Effect Related microRNAs Correlate with each Other and that of Histone Deacetylase Enzymes in Adult Hematological Malignancies with Emphasis on Acute Myeloid Leukemia.Semantic proximity Read ↗

Histone lysine demethylase KDM5B facilitates proliferation and suppresses apoptosis in human acute myeloid leukemia cells through the miR-140-3p/BCL2 axisSemantic proximity Read ↗

Translation Initiation Represents an Acute Myeloid Leukemia Cell Vulnerability That Can Be Co-Targeted With BCL-2 InhibitionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.