Article
Divergent Levels of Marker Chromosomes in an hiPSC-Based Model of Psychosis.
Stem cell reports - 14 Mar 2017
Tcw Julia, Carvalho Claudia M B, Yuan Bo, Gu Shen, Altheimer Alyssa N, McCarthy Shane, Malhotra Dheeraj, Sebat Jonathan, Siegel Arthur J, Rudolph Uwe, Lupski James R, Levy Deborah L, Brennand Kristen J
Abstract excerpt
In the process of generating presumably clonal human induced pluripotent stem cells (hiPSCs) from two carriers of a complex structural rearrangement, each having a psychotic disorder, we also serendipitously generated isogenic non-carrier control hiPSCs, finding that the rearrangement occurs as an extrachromosomal marker (mar) element. All confirmed carrier hiPSCs and differentiated neural progenitor cell lines...
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