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Article

Filaggrin loss-of-function mutations, atopic dermatitis and risk of actinic keratosis: results from two cross-sectional studies.

Journal of the European Academy of Dermatology and Venereology : JEADV - 1 Jun 2017

Andersen Y M F, Egeberg A, Balslev E, Jørgensen C L T, Szecsi P B, Stender S, Kaae J, Linneberg A, Gislason G, Skov L, Elias P M, Thyssen J P

Abstract excerpt

BACKGROUND: Common loss-of-function mutations in filaggrin gene (FLG) represent a strong genetic risk factor for atopic dermatitis (AD). Homozygous mutation carriers typically display ichthyosis vulgaris (IV) and many have concomitant AD. Previously, homozygous, but not heterozygous, filaggrin gene mutations have been associated with squamous cell carcinomas. OBJECTIVE: The first objective was to examine the...

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Identifiers

PMID: 28213896
DOI: 10.1111/jdv.14172

Genes

FLG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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