Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Filaggrin genotype determines functional and molecular alterations in skin of patients with atopic dermatitis and ichthyosis vulgaris.

PloS one - 1 Jan 2011

Winge Mårten C G, Hoppe Torborg, Berne Berit, Vahlquist Anders, Nordenskjöld Magnus, Bradley Maria, Törmä Hans

Abstract excerpt

BACKGROUND: Several common genetic and environmental disease mechanisms are important for the pathophysiology behind atopic dermatitis (AD). Filaggrin (FLG) loss-of-function is of great significance for barrier impairment in AD and ichthyosis vulgaris (IV), which is commonly associated with AD. The molecular background is, however, complex and various clusters of genes are altered, including inflammatory and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion
Share to Dermatitis, Atopic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Filaggrin Proteins

Share to Hydrogen-Ion Concentration

Share to Intermediate Filament Proteins

Share to Lipid Metabolism

Share to Surveys and Questionnaires

Source

Open in PubMed Open full text

Identifiers

PMID: 22164253
DOI: 10.1371/journal.pone.0028254
PMCID: PMC3229525

Genes

FLG
STS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Filaggrin genotype determines functional and molecular alterations in skin of patients with atopic dermatitis and ichthyosis vulgaris.PMID 22164253Read ↗

Filaggrin gene defects and the risk of developing allergic disorders.Semantic proximity Read ↗

Moisturizing treatment of patients with atopic dermatitis and ichthyosis vulgaris improves dry skin, but has a modest effect on gene expression regardless of FLG genotype.Semantic proximity Read ↗

Filaggrin gene polymorphisms in Iranian ichthyosis vulgaris and atopic dermatitis patientsSemantic proximity Read ↗

Mutations in the filaggrin gene in Han Chinese patients with atopic dermatitis.Semantic proximity Read ↗

Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function.Semantic proximity Read ↗

Genetics of Atopic Dermatitis: From DNA Sequence to Clinical RelevanceSemantic proximity Read ↗

Clinical characteristics of Korean patients with filaggrin-related atopic dermatitis.Semantic proximity Read ↗

Alterations in Epidermal Eicosanoid Metabolism Contribute to Inflammation and Impaired Late Differentiation in FLG-Mutated Atopic Dermatitis.Semantic proximity Read ↗

Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations.Semantic proximity Read ↗

Novel filaggrin mutation but no other loss-of-function variants found in Ethiopian patients with atopic dermatitis.Semantic proximity Read ↗

Ichthyosis vulgaris: novel FLG mutations in the German population and high presence of CD1a+ cells in the epidermis of the atopic subgroup.Semantic proximity Read ↗

One remarkable molecule: filaggrin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.