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Article

Filaggrin genotype determines functional and molecular alterations in skin of patients with atopic dermatitis and ichthyosis vulgaris.

PloS one - 1 Jan 2011

Winge Mårten C G, Hoppe Torborg, Berne Berit, Vahlquist Anders, Nordenskjöld Magnus, Bradley Maria, Törmä Hans

Abstract excerpt

BACKGROUND: Several common genetic and environmental disease mechanisms are important for the pathophysiology behind atopic dermatitis (AD). Filaggrin (FLG) loss-of-function is of great significance for barrier impairment in AD and ichthyosis vulgaris (IV), which is commonly associated with AD. T...

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Identifiers

PMID: 22164253
DOI: 10.1371/journal.pone.0028254
PMCID: PMC3229525

Genes

FLG
STS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22164253-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Filaggrin genotype determines functional and molecular alterations in skin of patients with atopic dermatitis and ichthyosis vulgaris.PMID 22164253Read ↗

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Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function.Semantic proximity Read ↗

Genetics of Atopic Dermatitis: From DNA Sequence to Clinical RelevanceSemantic proximity Read ↗

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Alterations in Epidermal Eicosanoid Metabolism Contribute to Inflammation and Impaired Late Differentiation in FLG-Mutated Atopic Dermatitis.Semantic proximity Read ↗

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