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Article

A prospective study of filaggrin null mutations in keratoconus patients with or without atopic disorders.

Dermatology (Basel, Switzerland) - 1 Jan 2011

Droitcourt C, Touboul D, Ged C, Ezzedine K, Cario-André M, de Verneuil H, Colin J, Taïeb A

Abstract excerpt

BACKGROUND: Atopic dermatitis (AD) is significantly associated with keratoconus (KC). An inherited component for KC has been suggested. Filaggrin (FLG) mutations are a strong genetic risk factor for AD. Since filaggrin is also expressed in the corneal epithelium, we hypothesized a common aetiology for ichthyosis vulgaris (IV), AD and KC. OBJECTIVES: We examined the prevalence of AD and IV in a KC population. We...

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Identifiers

PMID: 21701148
DOI: 10.1159/000328408

Genes

FLG

Variants

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