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Article

Germinal centre frequency is decreased in pancreatic lymph nodes from individuals with recent-onset type 1 diabetes.

Diabetologia - 1 Jul 2017

Willcox Abby, Richardson Sarah J, Walker Lucy S K, Kent Sally C, Morgan Noel G, Gillespie Kathleen M

Abstract excerpt

AIMS/HYPOTHESIS: Pancreatic lymph nodes (PLNs) are critical sites for the initial interaction between islet autoantigens and autoreactive lymphocytes, but the histology of PLNs in tissue from individuals with type 1 diabetes has not been analysed in detail. The aim of this study was to examine PLN tissue sections from healthy donors compared with those at risk of, or with recent-onset and longer-duration type 1...

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Share to Autoantigens
Share to Germinal Center

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Secreting Cells

Share to Islets of Langerhans

Share to Ki-67 Antigen

Share to Lymph Nodes

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Source

Open in PubMed Open full text

Identifiers

PMID: 28213757
DOI: 10.1007/s00125-017-4221-7
PMCID: PMC5487689

Genes

PLN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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