Article
Immunohistologic detection of the primary follicle (PF) in human fetal and newborn lymph node anlages.
Pathology, research and practice - 1 Sept 1993
Asano S, Akaike Y, Muramatsu T, Mochizuki M, Tsuda T, Wakasa H
Abstract excerpt
The primary follicle (PF) emerges as a globular nest of follicular dendritic cells (FDC) and lymphocytes in the lymph node anlage in the 16th gestational week. It increases in size with age but no germinal center is found until several months later, after birth. Using a panel of monoclonal antibodies, the authors have defined phenotypes of component cells of the PF. The PF contains a B-cell population including...
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