Article
Reduced frequency of two activating KIR genes in patients with sepsis.
Human immunology - 1 Apr 2017
Oliveira Luciana M, Portela Pamela, Merzoni Joice, Lindenau Juliana D, Dias Fernando S, Beppler Jaqueline, Graebin Pietra, Alho Clarice S, Schwartsmann Gilberto, Dal-Pizzol Felipe, Jobim Luiz Fernando, Jobim Mariana, Roesler Rafael
Abstract excerpt
Natural killer (NK) cell activity is regulated by activating and inhibitory signals transduced by killer cell immunoglobulin-like receptors (KIR). Diversity in KIR gene repertoire among individuals may affect disease outcome. Sepsis development and severity may be influenced by genetic factors affecting the immune response. Here, we examined sixteen KIR genes and their human leucocyte antigen (HLA) class I...
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