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Article

Structural and functional characterization of deep-sea thermophilic bacteriophage GVE2 HNH endonuclease.

Scientific reports - 13 Feb 2017

Zhang Likui, Xu Dandan, Huang Yanchao, Zhu Xinyuan, Rui Mianwen, Wan Ting, Zheng Xin, Shen Yulong, Chen Xiangdong, Ma Kesen, Gong Yong

Abstract excerpt

HNH endonucleases in bacteriophages play a variety of roles in the phage lifecycle as key components of phage DNA packaging machines. The deep-sea thermophilic bacteriophage Geobacillus virus E2 (GVE2) encodes an HNH endonuclease (GVE2 HNHE). Here, the crystal structure of GVE2 HNHE is reported. This is the first structural study of a thermostable HNH endonuclease from a thermophilic bacteriophage. Structural...

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Identifiers

PMID: 28211904
DOI: 10.1038/srep42542
PMCID: PMC5304195

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