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Article

Biochemical characterization and mutational studies of a thermostable endonuclease III from Sulfolobus islandicus REY15A.

International journal of biological macromolecules - 15 Dec 2021

Zhang Likui, Wang Lei, Wu Leilei, Jiang Donghao, Tang Chengxuan, Wu Ying, Wu Mai, Chen Min

Abstract excerpt

Endonuclease III (EndoIII), which is ubiquitous in bacteria, Archaea and eukaryotes, plays an important role in excising thymine glycol (Tg) from DNA. Herein, we present evidence that an EndoIII from the hyperthermophilic crenarchaeon Sulfolobus islandicus REY15A (Sis-EndoIII) is capable of removing Tg from DNA at high temperature. Biochemical data show that the optimal temperature and pH of Sis-EndoIII are...

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PMID: 34743941
DOI: 10.1016/j.ijbiomac.2021.10.143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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