Article
On the illusion of auxotrophy: met15Δ yeast cells can grow on inorganic sulfur, thanks to the previously uncharacterized homocysteine synthase Yll058w.
The Journal of biological chemistry - 1 Dec 2022
Van Oss S Branden, Parikh Saurin Bipin, Castilho Coelho Nelson, Wacholder Aaron, Belashov Ivan, Zdancewicz Sara, Michaca Manuel, Xu Jiazhen, Kang Yun Pyo, Ward Nathan P, Yoon Sang Jun, McCourt Katherine M, McKee Jake, Ideker Trey, VanDemark Andrew P, DeNicola Gina M, Carvunis Anne-Ruxandra
Abstract excerpt
Organisms must either synthesize or assimilate essential organic compounds to survive. The homocysteine synthase Met15 has been considered essential for inorganic sulfur assimilation in yeast since its discovery in the 1970s. As a result, MET15 has served as a genetic marker for hundreds of experiments that play a foundational role in eukaryote genetics and systems biology. Nevertheless, we demonstrate here...
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