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Article

Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells.

Oncogene - 20 Aug 2009

Sullivan N J, Sasser A K, Axel A E, Vesuna F, Raman V, Ramirez N, Oberyszyn T M, Hall B M

Abstract excerpt

Breast tumor interleukin-6 (IL-6) levels increase with tumor grade, and elevated serum IL-6 correlates with poor breast cancer patient survival. Epithelial-mesenchymal transition (EMT) phenotypes such as impaired E-cadherin expression or aberrant Vimentin induction are associated with enhanced metastasis and unfavorable clinical outcome in breast cancer. Despite this fact, few tumor microenvironment-derived...

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Source

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Identifiers

PMID: 19581928
DOI: 10.1038/onc.2009.180
PMCID: PMC5576031

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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