Article
TGF-β1-mediated fibrosis and ion channel remodeling are key mechanisms in producing the sinus node dysfunction associated with SCN5A deficiency and aging.
Circulation. Arrhythmia and electrophysiology - 1 Jun 2011
Hao Xiaojin, Zhang Yanmin, Zhang Xinzhao, Nirmalan Mahesh, Davies Laura, Konstantinou Dimitrios, Yin Fei, Dobrzynski Halina, Wang Xin, Grace Andrew, Zhang Henggui, Boyett Mark, Huang Christopher L-H, Lei Ming
Abstract excerpt
BACKGROUND: Mutations in the cardiac Na(+) channel gene (SCN5A) can adversely affect electric function in the heart, but effects can be age dependent. We explored the interacting effects of Scn5a disruption and aging on the pathogenesis of sinus node dysfunction in a heterozygous Scn5a knockout (Scn5a(+/-)) mouse model. METHODS AND RESULTS: We compared functional, histological, and molecular features in young (3...
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