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Article

HuCNS-SC Human NSCs Fail to Differentiate, Form Ectopic Clusters, and Provide No Cognitive Benefits in a Transgenic Model of Alzheimer's Disease.

Stem cell reports - 14 Feb 2017

Marsh Samuel E, Yeung Stephen T, Torres Maria, Lau Lydia, Davis Joy L, Monuki Edwin S, Poon Wayne W, Blurton-Jones Mathew

Abstract excerpt

Transplantation of neural stem cells (NSCs) can improve cognition in animal models of Alzheimer's disease (AD). However, AD is a protracted disorder, and prior studies have examined only short-term effects. We therefore used an immune-deficient model of AD (Rag-5xfAD mice) to examine long-term transplantation of human NSCs (StemCells Inc.; HuCNS-SCs). Five months after transplantation, HuCNS-SCs had engrafted and...

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Identifiers

PMID: 28199828
DOI: 10.1016/j.stemcr.2016.12.019
PMCID: PMC5312253

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