Article
Endothelial-specific deletion of autophagy-related 7 (ATG7) attenuates arterial thrombosis in mice.
The Journal of thoracic and cardiovascular surgery - 1 Sept 2017
Yau Jonathan W, Singh Krishna K, Hou Yan, Lei Xi, Ramadan Azza, Quan Adrian, Teoh Hwee, Kuebler Wolfgang M, Al-Omran Mohammed, Yanagawa Bobby, Ni Heyu, Verma Subodh
Abstract excerpt
BACKGROUND: Thrombosis persists as a leading cause of morbidity and mortality. Given that endothelial cells (ECs) play a central role in regulating thrombosis, understanding the molecular endothelial cues that regulate susceptibility or resistance to thrombosis have important translational implications. Accordingly, we evaluated the role of endothelial autophagy in the development of thrombosis. METHODS: We...
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