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Article

Overexpression of the cell cycle inhibitor p16INK4a promotes a prothrombotic phenotype following vascular injury in mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2011

Cardenas Jessica C, Owens A Phillip, Krishnamurthy Janakiraman, Sharpless Norman E, Whinna Herbert C, Church Frank C

Abstract excerpt

OBJECTIVE: Age-associated cellular senescence is thought to promote vascular dysfunction. p16(INK4a) is a cell cycle inhibitor that promotes senescence and is upregulated during normal aging. In this study, we examine the contribution of p16(INK4a) overexpression to venous thrombosis. METHODS AND RESULTS: Mice overexpressing p16(INK4a) were studied with 4 different vascular injury models: (1) ferric chloride...

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Source

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Identifiers

PMID: 21233453
DOI: 10.1161/ATVBAHA.110.221721
PMCID: PMC3086817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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