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Article

Correlation between the COL4A3, MMP-9, and TIMP-1 polymorphisms and risk of keratoconus.

Japanese journal of ophthalmology - 1 May 2017

Saravani Ramin, Yari Davood, Saravani Samira, Hasanian-Langroudi Farzaneh

Abstract excerpt

PURPOSE: Keratoconus (KC) is thinning of the central cornea. Its etiology is unknown, but it may result from degrading of collagen type IV. The major protein in the cornea is collagen. Matrix metalloproteinase-9 (MMP-9) is able to degrade collagen type IV from the basement membrane and extracellular matrix (ECM). MMP-9 enzymatic activity is inhibited by the tissue inhibitor of metalloproteinase-1 (TIMP-1). In the...

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Identifiers

PMID: 28197741
DOI: 10.1007/s10384-017-0503-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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