TNF-α Genetic Predisposition and Higher Expression of Inflammatory Pathway Components in Keratoconus.

doi:10.1167/iovs.16-21400

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Article

TNF-α Genetic Predisposition and Higher Expression of Inflammatory Pathway Components in Keratoconus.

Investigative ophthalmology & visual science - 1 Jul 2017

Arbab Muneeza, Tahir Saira, Niazi Muhammad Khizar, Ishaq Mazhar, Hussain Alamdar, Siddique Pir Muhammad, Saeed Sadia, Khan Wajid Ali, Qamar Raheel, Butt Azeem Mehmood, Azam Maleeha

Abstract excerpt

Purpose: To date keratoconus (KC) pathogenesis is undefined; however, the involvement of inflammatory pathways in disease development is becoming apparent. In the present study, we investigated the role of a promoter region polymorphism rs1800629 (-308G>A) in the inflammatory pathway component TNF-α and its effects on the expression of TNF-α and downstream molecules tumor necrosis factor receptor 1 and 2 (TNFR1...

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PMID: 28702675
DOI: 10.1167/iovs.16-21400

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RELA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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