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Article

Evaluation of possible relationship between COL4A4 gene polymorphisms and risk of keratoconus.

Cornea - 1 Mar 2015

Saravani Ramin, Hasanian-Langroudi Farzaneh, Validad Mohammad-Hosein, Yari Davood, Bahari Gholamreza, Faramarzi Mahmood, Khateri Mehdi, Bahadoram Somayeh

Abstract excerpt

PURPOSE: Keratoconus (KC) is a genetically heterogeneous corneal dystrophy with unknown etiology that causes loss of visual acuity. Evidence has shown that corneas from patients with KC contain reduced amounts of total collagen proteins, and collagen type IV has been suggested as a candidate gene in KC pathogenesis. This study aimed to evaluate the possible associations between collagen type IV alpha-4 chain...

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Identifiers

PMID: 25651396
DOI: 10.1097/ICO.0000000000000356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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