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Article

Copy number analysis identifies tumor suppressive lncRNAs in human osteosarcoma.

International journal of oncology - 1 Mar 2017

Xie Jianjun, Lin Dechen, Lee Dhong Hyun Tony, Akunowicz Jennifer, Hansen Marc, Miller Carl, Sanada Masashi, Kato Motohiro, Akagi Tadayuki, Kawamata Norihiko, Ogawa Seishi, Koeffler H Phillip

Abstract excerpt

Osteosarcoma (OS) has a high degree of chromosomal instability and total copy number (CN) changes. We examined 58 human OS samples including 40 primary tumors, 11 explants, and 7 cell lines using single nucleotide polymorphism (SNP) arrays, and revealed that 70% of the samples had one or more recurrent CN-neutral loss of heterozygosity (CNN‑LOH) also known as uniparental disomy (UPD). Importantly, 17% of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28197627
DOI: 10.3892/ijo.2017.3864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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