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Article

Metabotropic glutamate receptor 5 may be involved in macrophage plasticity.

Biological research - 14 Feb 2017

Shanshiashvili Lali, Tsitsilashvili Elene, Dabrundashvili Nino, Kalandadze Irine, Mikeladze David

Abstract excerpt

BACKGROUND: Macrophages are a functionally heterogeneous cell population and depending on microenvironments they polarize in two main groups: M1 and M2. Glutamic acid and glutamate receptors may participate in the regulation of macrophage plasticity. To investigate the role of glutamatergic systems in macrophages physiology, we performed the transfection of mGluR5 cDNAs into RAW-264.7 cells. RESULTS: Comparative...

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Identifiers

PMID: 28196513
DOI: 10.1186/s40659-017-0110-2
PMCID: PMC5310073

Genes

HMGB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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