The expression of two splice variants of metabotropic glutamate receptor subtype 5 in the rat brain and neuronal cells during development.

Abstract excerpt

We previously reported that a variant with extra amino acid residues exists in the metabotropic glutamate receptor subtype 5 (mGluR5). Either of the two isoforms, named mGluR5b and mGluR5a for the isoforms with and without the inserted sequence, respectively, generated Ca(2+)-activated Cl- current when expressed in Xenopus oocytes. We herein report that these two isoforms are produced by the alternative splicing...

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