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Article

VANGL2 regulates membrane trafficking of MMP14 to control cell polarity and migration.

Journal of cell science - 1 May 2012

Williams B Blairanne, Cantrell V Ashley, Mundell Nathan A, Bennett Andrea C, Quick Rachel E, Jessen Jason R

Abstract excerpt

Planar cell polarity (PCP) describes the polarized orientation of cells within the plane of a tissue. Unlike epithelial PCP, the mechanisms underlying PCP signaling in migrating cells remain undefined. Here, the establishment of PCP must be coordinated with dynamic changes in cell adhesion and extracellular matrix (ECM) organization. During gastrulation, the membrane type-1 matrix metalloproteinase (MT1-MMP or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Focal Adhesion Protein-Tyrosine Kinases

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Source

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Identifiers

PMID: 22357946
DOI: 10.1242/jcs.097964
PMCID: PMC3367937

Genes

MMP14
VANGL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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