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Article

Direct Isolation and Characterization of Human Nephron Progenitors.

Stem cells translational medicine - 1 Feb 2017

Da Sacco Stefano, Thornton Matthew E, Petrosyan Astgik, Lavarreda-Pearce Maria, Sedrakyan Sargis, Grubbs Brendan H, De Filippo Roger E, Perin Laura

Abstract excerpt

Mature nephrons originate from a small population of uninduced nephrogenic progenitor cells (NPs) within the cap mesenchyme. These cells are characterized by the coexpression of SIX2 and CITED1. Many studies on mouse models as well as on human pluripotent stem cells have advanced our knowledge of NPs, but very little is known about this population in humans, since it is exhausted before birth and strategies for...

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Source

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Identifiers

PMID: 28191781
DOI: 10.5966/sctm.2015-0429
PMCID: PMC5442819

Genes

CITED1
SIX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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