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Article

The role of ST2 and ST2 genetic variants in schistosomiasis.

The Journal of allergy and clinical immunology - 1 Nov 2017

Long Xin, Daya Michelle, Zhao Jianping, Rafaels Nicholas, Liang Huifang, Potee Joseph, Campbell Monica, Zhang Bixiang, Araujo Maria Ilma, Oliveira Ricardo R, Mathias Rasika A, Gao Li, Ruczinski Ingo, Georas Steve N, Vercelli Donata, Beaty Terri H, Barnes Kathleen C, Chen Xiaoping, Chen Qian

Abstract excerpt

BACKGROUND: Chronic schistosomiasis and its severe complication, periportal fibrosis, are characterized by a predominant Th2 response. To date, specific single nucleotide polymorphisms in ST2 have been some of the most consistently associated genetic variants for asthma. OBJECTIVE: We investigated the role of ST2 (a receptor for the Th2 cytokine IL-33) in chronic and late-stage schistosomiasis caused by...

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Source

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Identifiers

PMID: 28189770
DOI: 10.1016/j.jaci.2016.12.969
PMCID: PMC5550370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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