Article
An IL-13 promoter polymorphism associated with liver fibrosis in patients with Schistosoma japonicum.
PloS one - 1 Jan 2015
Long Xin, Chen Qian, Zhao Jianping, Rafaels Nicholas, Mathias Priyanka, Liang Huifang, Potee Joseph, Campbell Monica, Zhang Bixiang, Gao Li, Georas Steve N, Vercelli Donata, Beaty Terri H, Ruczinski Ingo, Mathias Rasika, Barnes Kathleen C, Chen Xiaoping
Abstract excerpt
The aim of this study was to determine whether two polymorphisms in the gene encoding IL13 previously associated with Schistosoma hematobium (S. hematobium) and S. mansoni infection are associated with S. japonicum infection. Single nucleotide polymorphisms (SNPs) rs1800925 (IL13/-1112C>T) and rs20541 (IL13R130Q) were genotyped in 947 unrelated individuals (307 chronically infected, 339 late-stage with liver...
Read the complete abstract on PubMed