Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79.

Genes & development - 1 Sept 2011

Ehrentraut Stefan, Hassler Markus, Oppikofer Mariano, Kueng Stephanie, Weber Jan M, Mueller Jonathan W, Gasser Susan M, Ladurner Andreas G, Ehrenhofer-Murray Ann E

Abstract excerpt

The silent information regulator 2/3/4 (Sir2/3/4) complex is required for gene silencing at the silent mating-type loci and at telomeres in Saccharomyces cerevisiae. Sir3 is closely related to the origin recognition complex 1 subunit and consists of an N-terminal bromo-adjacent homology (BAH) dom...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to DNA Methylation
Share to Gene Silencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histones

Share to Models, Molecular

Share to Protein Structure, Tertiary

Share to Saccharomyces cerevisiae

Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 21896656
DOI: 10.1101/gad.17175111
PMCID: PMC3175719

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21896656-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79.PMID 21896656Read ↗

Variants of the Sir4 Coiled-Coil Domain Improve Binding to Sir3 for Heterochromatin Formation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutational analysis of the Sir3 BAH domain reveals multiple points of interaction with nucleosomes.Semantic proximity Read ↗

Sir3-nucleosome interactions in spreading of silent chromatin in Saccharomyces cerevisiae.Semantic proximity Read ↗

Role of the conserved Sir3-BAH domain in nucleosome binding and silent chromatin assembly.Semantic proximity Read ↗

Insights into the impact of histone acetylation and methylation on Sir protein recruitment, spreading, and silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

A nonhistone protein-protein interaction required for assembly of the SIR complex and silent chromatin.Semantic proximity Read ↗

Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes.Semantic proximity Read ↗

Phylogenetic conservation and homology modeling help reveal a novel domain within the budding yeast heterochromatin protein Sir1.Semantic proximity Read ↗

Telomere anchoring at the nuclear periphery requires the budding yeast Sad1-UNC-84 domain protein Mps3.Semantic proximity Read ↗

Compensatory interactions between Sir3p and the nucleosomal LRS surface imply their direct interaction.Semantic proximity Read ↗

Sir3 C-terminal domain involvement in the initiation and spreading of heterochromatin.Semantic proximity Read ↗

A region of the nucleosome required for multiple types of transcriptional silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.