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Article

A nonhistone protein-protein interaction required for assembly of the SIR complex and silent chromatin.

Molecular and cellular biology - 1 Jun 2005

Rudner Adam D, Hall Brian E, Ellenberger Tom, Moazed Danesh

Abstract excerpt

Budding yeast silent chromatin, or heterochromatin, is composed of histones and the Sir2, Sir3, and Sir4 proteins. Their assembly into silent chromatin is believed to require the deacetylation of histones by the NAD-dependent deacetylase Sir2 and the subsequent interaction of Sir3 and Sir4 with these hypoacetylated regions of chromatin. Here we explore the role of interactions among the Sir proteins in the...

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Share to Acetylation
Share to Gene Silencing
Share to Heterochromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylases

Share to Silencer Elements, Transcriptional

Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Source

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Identifiers

PMID: 15899856
DOI: 10.1128/MCB.25.11.4514-4528.2005
PMCID: PMC1140625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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