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Article

SPAG1 promotes the development of AML by activating the ERK/MAPK signaling pathway and affects the chemotherapy sensitivity of venetoclax.

Neoplasma - 1 Sept 2022

Liu Lu, Liu Jing, Liu Xiao-Jun, Liu Meng-Han, Feng Xue-Feng, Yang Lin, Luo Jian-Min

Abstract excerpt

Sperm-associated antigen 1 (SPAG1) is considered to be associated with infertility and tumorigenesis. However, its function in acute myeloid leukemia (AML) remains unclear. In this study, we evaluated the expression level of SPAG1 and explored its clinical prognostic value in patients with AML, as well as its biological function in AML cells. SPAG1 is widely expressed in AML patients, resulting in a poor...

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Source

Identifiers

PMID: 35951456
DOI: 10.4149/neo_2022_220415N416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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