Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Application of a high-throughput swarm-based deep neural network Algorithm reveals SPAG5 downregulation as a potential therapeutic target in adult AML

6 Jan 2025

Abstract excerpt

Gene‒gene interactions play pivotal roles in disease pathogenesis and are fundamental in the development of targeted therapeutics, particularly through the elucidation of oncogenic gene drivers in cancer. The systematic analysis of pathways and gene interactions is critical in the drug discovery process for various cancer subtypes. SPAG5, known for its role in spindle formation during cell division, has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Multiple Myeloma Research and Treatments
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39762615
DOI: 10.1007/s10142-024-01514-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Application of a high-throughput swarm-based deep neural network Algorithm reveals SPAG5 downregulation as a potential therapeutic target in adult AMLPMID 39762615Read ↗

Application of a High-Throughput Swarm-Based Deep Neural Network Algorithm Reveals SPAG5 Downregulation as a Potential Therapeutic Target in Adult AMLSemantic proximity Read ↗

SCAMP2/5 as diagnostic and prognostic markers for acute myeloid leukemia.Semantic proximity Read ↗

Ensembling Deep Learning and Bioinformatics for Precision Treatment Recommendations: Application in Acute Myeloid LeukemiaSemantic proximity Read ↗

Oncogenic ASPM Is a Regulatory Hub of Developmental and Stemness Signaling in CancersSemantic proximity Read ↗

Upregulated mitosis-associated genes CENPE, CENPF, and DLGAP5 predict poor prognosis and chemotherapy resistance of Acute Myeloid LeukemiaSemantic proximity Read ↗

PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features.Semantic proximity Read ↗

Targeting of mutant-p53 and MYC as a novel strategy to inhibit oncogenic SPAG5 activity in triple negative breast cancer.Semantic proximity Read ↗

In-depth Inference of Transcriptional Regulatory Networks Identifies NPM1 as a Druggable Master Regulator in MedulloblastomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.