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Article

Optimized creation of glioblastoma patient derived xenografts for use in preclinical studies.

Journal of translational medicine - 9 Feb 2017

William Doreen, Mullins Christina Susanne, Schneider Björn, Orthmann Andrea, Lamp Nora, Krohn Mathias, Hoffmann Annika, Classen Carl-Friedrich, Linnebacher Michael

Abstract excerpt

BACKGROUND: Glioblastoma multiforme (GBM) is the most common and lethal brain tumor in adults, highlighting the need for novel treatment strategies. Patient derived xenografts (PDX) represent a valuable tool to accomplish this task. METHODS: PDX were established by implanting GBM tissue subcutaneously. Engraftment success was compared between NMRI Foxn1nu and NOD/SCID as well as between fresh and cryopreserved...

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Identifiers

PMID: 28183348
DOI: 10.1186/s12967-017-1128-5
PMCID: PMC5301415

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