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Article

Next-generation sequencing of the BRCA1 and BRCA2 genes for the genetic diagnostics of hereditary breast and/or ovarian cancer.

The Journal of molecular diagnostics : JMD - 1 Mar 2015

Trujillano Daniel, Weiss Maximilian E R, Schneider Juliane, Köster Julia, Papachristos Efstathios B, Saviouk Viatcheslav, Zakharkina Tetyana, Nahavandi Nahid, Kovacevic Lejla, Rolfs Arndt

Abstract excerpt

Genetic testing for hereditary breast and/or ovarian cancer mostly relies on laborious molecular tools that use Sanger sequencing to scan for mutations in the BRCA1 and BRCA2 genes. We explored a more efficient genetic screening strategy based on next-generation sequencing of the BRCA1 and BRCA2 genes in 210 hereditary breast and/or ovarian cancer patients. We first validated this approach in a cohort of 115...

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Identifiers

PMID: 25556971
DOI: 10.1016/j.jmoldx.2014.11.004

Genes

BRCA1
BRCA2

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