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Germline and somatic mutation profile in Cancer patients revealed by a medium-sized pan-Cancer panel.

Genomics - 1 Jul 2021

Li Zhaopei, Wang Hailong, Zhang Zhen, Meng Xiangwen, Liu Dujuan, Tang Yuanhua

Abstract excerpt

Gene mutation detection and the resulted precision-medicine therapy is transforming clinical practice. Here, we report the use of a custom-developed, medium-sized, pan-cancer probe panel for the detection of somatic and germline mutations. We used a hybridization capture-based NGS assay for targeted deep sequencing of all exons and selected introns of 181 key cancer driver genes, covering both inherited risks and...

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PMID: 33878367
DOI: 10.1016/j.ygeno.2021.04.029

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