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Article

Detection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencing.

Proceedings of the National Academy of Sciences of the United States of America - 13 Jul 2010

Walsh Tom, Lee Ming K, Casadei Silvia, Thornton Anne M, Stray Sunday M, Pennil Christopher, Nord Alex S, Mandell Jessica B, Swisher Elizabeth M, King Mary-Claire

Abstract excerpt

Inherited loss-of-function mutations in the tumor suppressor genes BRCA1, BRCA2, and multiple other genes predispose to high risks of breast and/or ovarian cancer. Cancer-associated inherited mutations in these genes are collectively quite common, but individually rare or even private. Genetic testing for BRCA1 and BRCA2 mutations has become an integral part of clinical practice, but testing is generally limited...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 20616022
DOI: 10.1073/pnas.1007983107
PMCID: PMC2906584

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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