Article
[Transcription factor RUNX1].
Molekuliarnaia biologiia - 1 Jan 2000
Markova E N, Petrova N V, Razin S V, Kantidze O L
Abstract excerpt
Transcription factor RUNX1 is one of the key regulatory proteins in vertebrates. It controls hematopoiesis and angiogenesis. It is indispensable during embryogenesis for the emergence of sites of definitive hematopoiesis and later in mature organisms for bone marrow blood stem cells differentiation. Moreover, RUNX1 gene is a frequent target for chromosomal translocations which cause acute forms of leukemia. A lot...
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