Article
Evaluating the association of multiple single nucleotide polymorphisms with response to gemcitabine and platinum combination chemotherapy in urothelial carcinoma of the bladder .
International journal of clinical pharmacology and therapeutics - 1 Mar 2017
Alanee Shaheen R, Shah Sohela, Zabor Emily C, Vijai Joseph, Ostrovnaya Irina, Garcia-Grossman Ilana R, Pendse Deepa V, Littman Jason, Regazzi Ashley M, Offit Kenneth, Bajorin Dean F
Abstract excerpt
OBJECTIVE: To examine germline single nucleotide polymorphisms (SNPs) as markers of response to gemcitabine platinum (GP) combination chemotherapy in urothelial carcinoma (UC). METHODS: Saliva or blood was prospectively collected from 216 patients treated with GP for UC of the bladder between 1991 and 2011. Based on reported associations with gemcitabine and cisplatin response or putative mechanisms of...
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